Mikhail Blagosklonny, an oncologist, defined aging as “an exponential increase of the probability of age with death.” He insisted that all elderly humans and other mammals die from age-related diseases, resulting from natural causes. Age-related diseases such as cancer, cardiovascular diseases, diabetes, Alzheimer and Parkinson diseases, are bio markers of aging. Cellular aging is an MTOR-dependent process. The MTOR pathway is activated by growth factors, nutrients, hormones, oxygen and other conditions like obesity. MTOR, which is a sensing pathway in each cell, initiates certain functions of differentiated cells and cellular mass growth. MTOR causes cellular hyperfunctions and hypertrophy, which in turn alters homeostasis, leading to age-related diseases. Cancer slows aging through interventions such as calorie restrictions. However, rapamycin, a common cancer drug, is a strong inhibitor of MTOR, which delays cancer and slows aging. Visit ResearchGate to keep up to date with Mikhail’s latest work.
About Mikhail Blagosklonny
Mikhail Blagosklonny has spent many years studying cancer and aging. He advances his mission of developing innovative therapies through his current role at Roswell Park Cancer Institute as the Professor of oncology. The scientist pursued his degree at First Pavlov State Medical University. Later, he secured a job at New York Medical College in Valhalla where he worked as an associate professor of medicine. After a while, he joined Ordway Research Institute in Albany where he worked as a senior scientist until 2009 when he was appointed to serve as a professor at Roswell Park Cancer Institute. His diversified research interests revolve around cancer and targeted cancer therapies that ensure that normal cells are not damaged by cancer cells
The cancer therapy expert holds various editorial positions, including being the editor-in chief of Oncotarget and Cell Cycle. He is the co-founding editor of Aging, which ranks second among the leading journals in aging research. Mikhail Blagosklonny is also a founding member of 700 for science, a group consisting of commercialization experts, who work to create a support system of grassroots for innovative biotechnology developments. Over the years, he has published different works, including drugs and treatment for cancer and age-related diseases, increasing healthy lifespan by suppressing aging, the proximal cause of aging, and the restriction point of the cell cycle. View Mikhail’s profile on Google Scholar.